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MLK2/MAP3K10 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q02779 |
| Other Accession | Q02779 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 103694 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MLK2/MAP3K10 |
| Epitope Specificity | 751-850/954 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Contains 1 SH3 domain. |
| SUBUNIT | Homodimer (By similarity). |
| Post-translational modifications | Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]. |
| Gene ID | 4294 |
|---|---|
| Other Names | MEKK10; MLK2; MST; M3K10_HUMAN; MAP3K10; Mixed lineage kinase 2; Protein kinase MST; 2.7.11.25; M3K10_MOUSE; mitogen-activated protein kinase kinase kinase 10; MKN28 kinase; MKN28 derived nonreceptor_type serine/threonine kinase |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MAP3K10 |
|---|---|
| Synonyms | MLK2, MST |
| Function | Activates the JUN N-terminal pathway. |
| Tissue Location | Expressed in brain and skeletal muscle. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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