癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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ZNF703 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9H7S9 |
| Other Accession | Q9H7S9 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58222 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZNF703 |
| Epitope Specificity | 221-320/590 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the Elbow/Noc family. Contains 1 C2H2-type zinc finger. |
| DISEASE | Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Gene ID | 80139 |
|---|---|
| Other Names | NLZ1; ZEPPO1; ZNF503L; ZPO1; 1110032O19Rik; Csmn1; End2; Znf703; ZN703_HUMAN; Zinc finger elbow-related proline domain protein 1; ZN703_MOUSE; Zfp703; zinc finger protein 703; NocA-like zinc finger 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ZNF703 |
|---|---|
| Synonyms | ZEPPO1, ZPO1 |
| Function | Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Expressed in mammary epithelium. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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