癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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GCP4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UGJ1 |
| Other Accession | Q9UGJ1 |
| Predicted | Rat, Pig, Human, Mouse, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 76089 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GCP4 |
| Epitope Specificity | 101-200/667 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the TUBGCP family. |
| SUBUNIT | Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with NINL. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The gamma-Tubulin complex is composed of gamma Tubulin and the gamma-Tubulin complex-associated proteins GCP2, GCP3, GCP4, GCP5 and GCP6, all of which are essential components of microtubule organizing centers. gamma-Tubulin complex components are localized to both the centrosome, where they are involved in microtubule nucleation, and to the cytoplasm, where they exist as soluble complexes that can be recruited to the centrosome as needed. Although the GCP proteins are related, they have distinct roles which contribute to the proper function of the gamma-Tubulin complex. GCP4 (gamma-tubulin complex component 4), also known as TUBGCP4, is a ubiquitously expressed 667 amino acid member of the gamma-Tubulin complex that localizes to the metaphase spindle during mitosis. In response to proteosome inhibition, GCP4 exhibits increased accumulation at the pericentiolar material where it participates in microtubule organization and nucleation. |
| Gene ID | 27229 |
|---|---|
| Other Names | 76P; GCP-4; GCP4; Grip76; MCCRP3; 4932441P04Rik; D2Ertd435e; GCP4_HUMAN; TUBGCP4; hGCP4; Gamma-ring complex protein 76 kDa (h76p | hGrip76); GCP4_MOUSE; tubulin gamma complex component 4; tubulin, gamma complex associated protein 4; tubulin gamma complex associated protein 4; gamma-tubulin complex protein 4; gamma-ring complex protein 76 kDa |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TUBGCP4 |
|---|---|
| Synonyms | 76P, GCP4 |
| Function | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| Tissue Location | Ubiquitously expressed. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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