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QARS/Glutamyl Prolyl tRNA synthetase/ProRS Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P47897 |
| Other Accession | P47897 |
| Reactivity | Rat, Mouse |
| Predicted | Pig, Human, Chicken, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 87799 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ProRS |
| Epitope Specificity | 651-750/1512 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family. In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family. Contains 3 WHEP-TRS domains. |
| SUBUNIT | Component of the multisynthetase complex which iscomprised of a bifunctional glutamyl-prolyl-tRNA synthetase, themonospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl,arginyl, and aspartyl-tRNA synthetases as well as three auxiliaryproteins, p18, p48 and p43. Interacts with DUS2L. Component of theGAIT complex; in humans the complex assembly seems to be a two-stepprocess in which EPRS first associates with SYNCRIP to form apre-GAIT complex which is deficient in GAIT element binding. |
| Post-translational modifications | Phosphorylated at Ser-886 by CDK5 in a IFN-gamma-dependent manner; this phosphorylation activates assembly of the GAIT (IFN-gamma-activated inhibitor of translation) complex, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. Aminoacyl-tRNA synthetases function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. ProRS (Prolyl-tRNA synthetase), also known as EPRS, EARS, PARS, QARS, QPRS, PIG32 or GLUPRORS, is a 1,512 amino acid protein that contains three WHEP-TRS domains and belongs to both the class-I and class-II aminoacyl-tRNA synthetase family. Functioning as a component of the multisynthase complex, ProRS uses ATP to catalyze the conversion of L-glutamate and tRNA(Glu) to L-glutamyl-tRNA(Glu), as well as the conversion of L-proline and tRNA(Pro) to L-prolyl-tRNA(Pro). |
| Gene ID | 5859 |
|---|---|
| Other Names | GLNRS; MSCCA; PRO2195; QARS; SYQ_HUMAN; QARS1; Glutaminyl-tRNA synthetase (GlnRS); 6.1.1.18; glutaminyl-tRNA synthetase 1; glutaminyl-tRNA synthetase; glutamine tRNA ligase |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | QARS1 (HGNC:9751) |
|---|---|
| Synonyms | QARS |
| Function | Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). |
| Cellular Location | Cytoplasm, cytosol. Cytoplasm |
| Tissue Location | Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100203
