NME3 Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P, IHC-F, IF
Primary Accession	Q13232
Other Accession	Q13232
Host	Rabbit
Clonality	Polyclonal
Calculated MW	19015 Da
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human NME3
Epitope Specificity	81-169/169
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SIMILARITY	Belongs to the NDK family.
DISEASE	Preferentially expressed at early stages of myeloid differentiation of highly purified CD34+ cells.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Additional Information
Gene ID	4832
Other Names	DR-nm23; NDPK-C; NDPKC; NM23-H3; NM23H3; c371H6.2; 1810009F08Rik; Ndk3; Nm23-DR; Nm23-M3; NDK3_HUMAN; NME3; NDK 3; NDP kinase 3; Nucleoside diphosphate kinase C (NDPKC); 2.7.4.6; NDK3_MOUSE; NME/NM23 nucleoside diphosphate kinase 3; non-metastatic cells 3, protein expressed in
Dilution	IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	NME3 (HGNC:7851)
Function	Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:11277919, PubMed:30587587, PubMed:39337255). In vitro, can also use other phosphate donors such as UTP and GTP (PubMed:30587587, PubMed:39337255). Independently of its nucleoside diphosphate kinase activity, involved in mitochondrial membrane tethering, a prerequisite for fusion through direct membrane-binding and hexamerization (PubMed:30587587, PubMed:37584589). Involved in DNA repair of both single- and double-stranded breaks by associating with the ribonucleotide reductase (RNR) complex via interaction with the histone acetyltransferase KAT5, facilitating recruitment to DNA damage sites independently of its kinase activity (PubMed:26945015). Inhibits granulocyte differentiation (PubMed:7638209). May be required for ciliary function during renal development (By similarity).
Cellular Location	Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250\|UniProtKB:Q9WV85}