癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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ME3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q16798 |
| Other Accession | Q16798 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67068 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ME3 |
| Epitope Specificity | 1-100/604 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] |
| Gene ID | 10873 |
|---|---|
| Other Names | NADP-ME; 1700020C08Rik; B230207H15Rik; MAON_HUMAN; ME3; Malic enzyme 3; 1.1.1.40; malic enzyme 3, NADP(+)-dependent, mitochondrial; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ME3 (HGNC:6985) |
|---|---|
| Function | Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+), and is able to reverse the reaction but only with significantly lower efficiency (PubMed:7818469). Can also catalyze the decarboxylation of oxaloacetate into pyruvate (By similarity). |
| Cellular Location | Mitochondrion matrix. |
| Tissue Location | Expressed predominantly in organs with a low- division rate |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100230
