癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
STK36 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9NRP7 |
| Other Accession | Q9NRP7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 143995 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human STK36 |
| Epitope Specificity | 21-120/1315 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain. |
| SUBUNIT | Interacts with SPAG16 and KIF27 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Serine/threonine protein kinase required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. |
| Gene ID | 27148 |
|---|---|
| Other Names | CILD46; FU; 1700112N14Rik; B930045J24; Fused; mKIAA1278; STK36_HUMAN; STK36; Fused homolog; 2.7.11.1; KIAA1278; STK36_MOUSE; serine/threonine kinase 36; serine/threonine kinase 36 (fused homolog, Drosophila); fused homolog (Drosophila) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1ug/Test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | STK36 {ECO:0000303|PubMed:31279575, ECO:0000312|HGNC:HGNC:17209} |
|---|---|
| Function | Serine/threonine protein kinase which plays an important role in the smoothened pathway by regulating the activity of GLI transcription factors (PubMed:10806483, PubMed:28543983, PubMed:31279575, PubMed:38096226). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483, PubMed:31279575, PubMed:38096226). Acts by mediating phosphorylation of GLI proteins, promoting their dissociation from SUFU (PubMed:28543983, PubMed:31279575, PubMed:38096226). Also catalyzes phosphorylation of ULK4 adapter (PubMed:38096226). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (PubMed:28543983). Essential for construction of the central pair apparatus of motile cilia (PubMed:28543983). |
| Cellular Location | Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm Nucleus. Note=STK36 and ULK4 are mutually dependent for localization to ciliary tip (PubMed:38096226). Low levels also present in the nucleus (PubMed:10806483) |
| Tissue Location | Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells (PubMed:10806483). Expressed in respiratory epithelial cells of the lung (PubMed:28543983). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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