癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PPM2C Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9P0J1 |
| Other Accession | Q9P0J1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61054 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PPM2C |
| Epitope Specificity | 51-150/537 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the PP2C family. |
| SUBUNIT | Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit (By similarity). |
| DISEASE | Defects in PDP1 are the cause of pyruvate dehydrogenase phosphatase deficiency (PDP deficiency) [MIM:608782]. PDP deficiency results in lactic acidosis leading to neurological dysfunction. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | PPM2C is a protein similar to members of the protein phosphatase 2C (PP2C) family. It is a catalytic subunit of the mitochondrial matrix phosphatase and is involved in reactivation of the pyruvate dehydrogenase complex. |
| Gene ID | 54704 |
|---|---|
| Other Names | PDH; PDP; PDPC; PDPC 1; PPM2A; PPM2C; Gm1024; PDP1_HUMAN; PDP1; PDP 1; Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1 (PDPC 1); 3.1.3.43; PDP1_MOUSE; PDP1_RAT; pyruvate dehydrogenase phosphatase catalytic subunit 1; protein phosphatase 2C, magnesium-dependent, catalytic subunit; protein phosphatase, Mg2+/Mn2+ dependent 2A |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PDP1 (HGNC:9279) |
|---|---|
| Synonyms | PDP, PPM2C |
| Function | Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. |
| Cellular Location | Mitochondrion. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP100263
