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ERVFRD-1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IP |
|---|---|
| Primary Accession | P60508 |
| Other Accession | P60508 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59523 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HERV-FRD |
| Epitope Specificity | 331-430/538 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily. |
| SUBUNIT | The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity). |
| Post-translational modifications | Specific enzymatic cleavages in vivo yield the mature SU and TM proteins (By similarity).The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. Can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.SU mediates receptor recognition (By similarity).TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). |
| Gene ID | 405754 |
|---|---|
| Other Names | ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD; UNQ6191; envFRD; SYCY2_HUMAN; ERVFRD-1; Endogenous retrovirus group FRD member 1; Envelope polyprotein; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; endogenous retrovirus group FRD member 1, envelope; endogenous retrovirus group FRD, member 1; syncytin 2 |
| Dilution | WB=1:500-2000,IP=1:50-200 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ERVFRD-1 |
|---|---|
| Synonyms | ERVFRDE1 |
| Function | This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). |
| Cellular Location | Virion. [Transmembrane protein]: Cell membrane; Single-pass membrane protein |
| Tissue Location | Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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