癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TIMM23 Mouse mAb
- 产品详情
- 实验流程
Application 
| WB, IF, IP, E |
|---|---|
| Primary Accession | O14925 |
| Other Accession | O14925 |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 21943 Da |
| Physical State | Liquid |
| Immunogen | Recombinant human TIMM23 protein |
| Epitope Specificity | 31-209/209 |
| Isotype | IgG2b,k |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the Tim17/Tim22/Tim23 family. |
| SUBUNIT | Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | TIMM23 nomenclature and NM_006327.2 were associated with GeneID:10431 in build 37.1. Because of assembly problems in this region, it was later determined that GeneID:100287932 correctly represents the location of TIMM23. TIMM23 is now associated with GeneID:100287932 and NM_006327.2. [17 Mar 2010] |
| Gene ID | 100287932 |
|---|---|
| Other Names | TIM23_HUMAN; TIMM23; TIM23; translocase of inner mitochondrial membrane 23; translocase of inner mitochondrial membrane 23 homolog (yeast) |
| Dilution | WB=1:100-1000,IF=1:100-500,IP=1:20-100,ELISA=1:30-3000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TIMM23 |
|---|---|
| Synonyms | TIM23 |
| Function | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (PubMed:10339406). Has a role in the activation of stress-induced mitophagy by protecting PINK1 from OMA1-mediated degradation and facilitating its accumulation at the outer mitochondrial membrane in response to depolarization (PubMed:37160114). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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