Anti-CD178-AcalephFluor647-labled

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	FC, IF/IC
Primary Accession	P41047
Reactivity	Mouse
Clonality	Monoclonal
Calculated MW	31442 Da

Additional Information
Gene ID	14103
Other Names	APT1LG1; CD95L; FASL; TNFSF6; Tumor necrosis factor ligand superfamily member 6; Apoptosis antigen ligand; APTL; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; CD antigen CD178)
Target/Specificity	Recognizes mouse CD178
Dilution	FC~~1:10~50 IF/IC~~N/A
Format	Armenian Hamster IgG. Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% sodium azide.
Storage	Store at -20 °C.Stable for 12 months from date of receipt

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	Faslg
Synonyms	Apt1lg1, Cd95l, Fasl, gld, Tnfsf6
Function	Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:7511063). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:19794494, PubMed:7532682). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (PubMed:19794494). TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance (PubMed:10779162). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarity).
Cellular Location	[Isoform FasL]: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen {ECO:0000250\|UniProtKB:P48023}. Lysosome lumen {ECO:0000250\|UniProtKB:P48023}. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane. {ECO:0000250\|UniProtKB:P48023} [FasL intracellular domain]: Nucleus {ECO:0000250\|UniProtKB:P48023}. Note=The FasL ICD cytoplasmic form is translocated into the nucleus. {ECO:0000250\|UniProtKB:P48023}
Tissue Location	Expressed in T-cells (PubMed:19794494). Expressed in natural killer cells (PubMed:7532682).