癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PP1R14C Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8TAE6 |
| Other Accession | NP_112211.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17843 Da |
| Antigen Region | 126-155 aa |
| Gene ID | 81706 |
|---|---|
| Other Names | Protein phosphatase 1 regulatory subunit 14C, Kinase-enhanced PP1 inhibitor, PKC-potentiated PP1 inhibitory protein, Serologically defined breast cancer antigen NY-BR-81, PPP1R14C, KEPI |
| Target/Specificity | This PP1R14C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-155 amino acids from the C-terminal region of human PP1R14C. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PP1R14C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PPP1R14C |
|---|---|
| Synonyms | KEPI |
| Function | Inhibitor of the PP1 regulatory subunit PPP1CA. |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein |
| Tissue Location | Detected in breast cancer. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM].
REFERENCES
Daskalow, K., et al. Anticancer Res. 30(5):1573-1578(2010)
Scholz, S.W., et al. Ann. Neurol. 65(5):610-614(2009)
Burgner, D., et al. PLoS Genet. 5 (1), E1000319 (2009) :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Liu, Q.R., et al. J. Biol. Chem. 277(15):13312-13320(2002)
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