癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CAMK2N1 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z7J9 |
| Other Accession | Q9JI15, Q6QWF9, A7MBG3, NP_061054.2 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 8553 Da |
| Antigen Region | 37-65 aa |
| Gene ID | 55450 |
|---|---|
| Other Names | Calcium/calmodulin-dependent protein kinase II inhibitor 1, CaMKII inhibitory protein alpha, CaMKIIN-alpha, CAMK2N1 |
| Target/Specificity | This CAMK2N1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the C-terminal region of human CAMK2N1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CAMK2N1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CAMK2N1 |
|---|---|
| Function | Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval- induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post- myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity). |
| Cellular Location | Synapse {ECO:0000250|UniProtKB:Q6QWF9}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JI15}. Postsynaptic density {ECO:0000250|UniProtKB:Q6QWF9} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Wang, C., et al. J. Biol. Chem. 283(17):11565-11574(2008)
Meng, F., et al. Brain Res. 967 (1-2), 161-169 (2003) :
Sedelnikova, A., et al. Int. J. Dev. Neurosci. 20 (3-5), 237-246 (2002) :
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¥ 1,250.00
Cat# AP10235b
