癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NEU4 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8WWR8 |
| Other Accession | NP_001161072.1, NP_542779.2, NP_001161074.1, NP_001161071.1, NP_001161073.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51572 Da |
| Antigen Region | 423-452 aa |
| Gene ID | 129807 |
|---|---|
| Other Names | Sialidase-4, N-acetyl-alpha-neuraminidase 4, NEU4 |
| Target/Specificity | This NEU4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-452 amino acids from the C-terminal region of human NEU4. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NEU4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NEU4 (HGNC:21328) |
|---|---|
| Function | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Efficiently hydrolyzes gangliosides including alpha- (2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15213228, PubMed:15847605, PubMed:21521691). Hydrolyzes poly- alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605). |
| Cellular Location | [Isoform 1]: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8BZL1} Note=Predominantly associates with endoplasmic reticulum membranes Only a small fraction associates with mitochondrial and plasma membranes. |
| Tissue Location | [Isoform 1]: Predominant form in liver. Also expressed in brain, kidney and colon. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
REFERENCES
Bigi, A., et al. Glycobiology 20(2):148-157(2010)
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)
Miyagi, T., et al. Proteomics 8(16):3303-3311(2008)
Stamatos, N.M., et al. FEBS J. 272(10):2545-2556(2005)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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