癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LHFPL5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8TAF8 |
| Other Accession | Q5PPI7, Q4KL25, NP_872354.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24201 Da |
| Antigen Region | 186-214 aa |
| Gene ID | 222662 |
|---|---|
| Other Names | Tetraspan membrane protein of hair cell stereocilia, Lipoma HMGIC fusion partner-like 5 protein, LHFPL5, TMHS |
| Target/Specificity | This LHFPL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-214 amino acids from the C-terminal region of human LHFPL5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LHFPL5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LHFPL5 (HGNC:21253) |
|---|---|
| Function | Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of the shorter stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore- forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. Functionally couples PCDH15 to the transduction channel. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q4KL25}; Multi-pass membrane protein. Note=Efficient localization to the plasma membrane requires the presence of PCDH15 {ECO:0000250|UniProtKB:Q4KL25} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis.
REFERENCES
Cosetti, M., et al. Ann. Otol. Rhinol. Laryngol. 117(11):827-833(2008)
Shabbir, M.I., et al. J. Med. Genet. 43(8):634-640(2006)
Longo-Guess, C.M., et al. Proc. Natl. Acad. Sci. U.S.A. 102(22):7894-7899(2005)
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