癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DEGS2 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q6QHC5 |
| Other Accession | Q8R2F2, Q0II71, NP_996801.2 |
| Reactivity | Human |
| Predicted | Mouse, Bovine, Rat, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37197 Da |
| Antigen Region | 261-290 aa |
| Gene ID | 123099 |
|---|---|
| Other Names | Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2, 1---, 114--, Degenerative spermatocyte homolog 2, DEGS2 (HGNC:20113), C14orf66 |
| Target/Specificity | This DEGS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids from the C-terminal region of human DEGS2. |
| Dilution | WB~~1:2000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DEGS2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DEGS2 (HGNC:20113) |
|---|---|
| Synonyms | C14orf66 |
| Function | Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R2F2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8R2F2} |
| Tissue Location | Highly expressed in skin, intestine and kidney. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DEGS2 encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase.
REFERENCES
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Mizutani, Y., et al. FEBS Lett. 563 (1-3), 93-97 (2004) :
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