癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ORMDL3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 6
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N138 |
| Other Accession | Q6QI25, Q9CPZ6, Q5XJR6, Q0VD15, Q9CQZ0, Q53FV1, Q5E972, Q5XH57, Q9P0S3, Q8JFB7, Q29RQ9, NP_644809.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Rat, Zebrafish, Bovine, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17495 Da |
| Antigen Region | 53-81 aa |
| Gene ID | 94103 |
|---|---|
| Other Names | ORM1-like protein 3, ORMDL3 |
| Target/Specificity | This ORMDL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the Central region of human ORMDL3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ORMDL3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ORMDL3 |
|---|---|
| Function | Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505, PubMed:30700557, PubMed:37308477). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (PubMed:37308477). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen and thymus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
REFERENCES
Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010) Liu, X., et al. Nat. Genet. 42(8):658-660(2010) Halapi, E., et al. Eur. J. Hum. Genet. 18(8):902-908(2010) Dobbins, S.E., et al. Int. J. Cancer (2010) In press : McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
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