癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RPH3AL Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9UNE2 |
| Other Accession | NP_008918.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34464 Da |
| Antigen Region | 208-237 aa |
| Gene ID | 9501 |
|---|---|
| Other Names | Rab effector Noc2, No C2 domains protein, Rabphilin-3A-like protein, RPH3AL, NOC2 |
| Target/Specificity | This RPH3AL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the C-terminal region of human RPH3AL. |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RPH3AL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RPH3AL |
|---|---|
| Synonyms | NOC2 |
| Function | Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells. |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells |
| Tissue Location | Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver Also detected in epithelial cells. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press : Shanmugam, C., et al. Biotech Histochem 84(2):39-45(2009) Katkoori, V.R., et al. Front. Biosci. 13, 1050-1061 (2008) : Matsumoto, M., et al. Proc. Natl. Acad. Sci. U.S.A. 101(22):8313-8318(2004) Manabe, S., et al. Biochem. Biophys. Res. Commun. 316(1):218-225(2004)
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