癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SPRR2A Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P35326 |
| Other Accession | NP_005979.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 7965 Da |
| Antigen Region | 48-72 aa |
| Gene ID | 6700 |
|---|---|
| Other Names | Small proline-rich protein 2A, SPR-2A, 2-1, SPRR2A |
| Target/Specificity | This SPRR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-72 amino acids from the C-terminal region of human SPRR2A. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SPRR2A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SPRR2A {ECO:0000303|PubMed:34735226, ECO:0000312|HGNC:HGNC:11261} |
|---|---|
| Function | Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (PubMed:34735226). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (PubMed:8325635). |
| Cellular Location | Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen. |
| Tissue Location | Expressed in intestine; selectively expressed in goblet cells. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
REFERENCES
Kainu, K., et al. Exp. Dermatol. 18(2):109-115(2009)
Demetris, A.J., et al. J. Hepatol. 48(2):276-288(2008)
Tong, L., et al. Invest. Ophthalmol. Vis. Sci. 47(5):1938-1946(2006)
Hong, S.H., et al. Mol. Cells 17(3):477-484(2004)
Cabral, A., et al. J. Biol. Chem. 278(20):17792-17799(2003)
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