癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RT4I1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q8WWV3 |
| Other Accession | NP_116119.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43590 Da |
| Antigen Region | 335-363 aa |
| Gene ID | 84816 |
|---|---|
| Other Names | Reticulon-4-interacting protein 1, mitochondrial, NOGO-interacting mitochondrial protein, RTN4IP1, NIMP |
| Target/Specificity | This RT4I1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 amino acids from the C-terminal region of human RT4I1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RT4I1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RTN4IP1 {ECO:0000303|PubMed:37884807, ECO:0000312|HGNC:HGNC:18647} |
|---|---|
| Function | NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway (PubMed:37884807). Required for the O- methyltransferase activity of COQ3 (PubMed:37884807). Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro (PubMed:37884807). However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo (PubMed:37884807). May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (By similarity). Appears to be a potent inhibitor of regeneration following spinal cord injury (By similarity). |
| Cellular Location | Mitochondrion matrix. Mitochondrion outer membrane. Note=Mainly localizes to the mitochondrial matrix (PubMed:37884807). Also colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria (PubMed:26593267) |
| Tissue Location | Widely expressed in mitochondria-enriched tissues (PubMed:12067236). Found in heart, muscle, kidney, liver, brain and placenta (PubMed:12067236). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a novel mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. The interaction of reticulon 4 with mitochondrial proteins may provide insight into the mechanisms for reticulon-induced inhibition of neurite growth.
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Domeniconi, M., et al. Neuron 35(2):283-290(2002)
Hu, W.H., et al. J. Neurochem. 81(1):36-45(2002)
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