癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
BCLAF1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NYF8 |
| Other Accession | NP_055554.1, NP_001070908.1, NP_001070909.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 106122 Da |
| Antigen Region | 658-687 aa |
| Gene ID | 9774 |
|---|---|
| Other Names | Bcl-2-associated transcription factor 1, Btf, BCLAF1, BTF, KIAA0164 |
| Target/Specificity | This BCLAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 658-687 amino acids from the C-terminal region of human BCLAF1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BCLAF1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BCLAF1 |
|---|---|
| Synonyms | BTF, KIAA0164 |
| Function | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. |
| Cellular Location | Cytoplasm. Nucleus. Nucleus speckle. Nucleus, nucleoplasm |
| Tissue Location | Ubiquitous. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Sarras, H., et al. ScientificWorldJournal 10, 1450-1461 (2010) :
Renert, A.F., et al. J. Proteome Res. 8(10):4810-4822(2009)
Liu, H., et al. Mol. Cell. Biol. 27(24):8480-8491(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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