癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PPRC1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q5VV67 |
| Other Accession | Q6NZN1, NP_055877.3 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 177544 Da |
| Antigen Region | 1636-1664 aa |
| Gene ID | 23082 |
|---|---|
| Other Names | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1, PGC-1-related coactivator, PRC, PPRC1, KIAA0595 |
| Target/Specificity | This PPRC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1636-1664 amino acids from the C-terminal region of human PPRC1. |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PPRC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPRC1 |
|---|---|
| Synonyms | KIAA0595 |
| Function | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. |
| Cellular Location | Nucleus. Note=Colocalizes with NRF1. |
| Tissue Location | Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.
REFERENCES
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
Vercauteren, K., et al. J. Biol. Chem. 284(4):2307-2319(2009)
Raharijaona, M., et al. PLoS ONE 4 (11), E7964 (2009) :
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Vercauteren, K., et al. J. Biol. Chem. 283(18):12102-12111(2008)
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