癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CCDC39 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UFE4 |
| Other Accession | NP_852091.1 |
| Reactivity | Human, Hamster, Mouse |
| Predicted | Bovine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 109901 Da |
| Antigen Region | 770-798 aa |
| Gene ID | 339829 |
|---|---|
| Other Names | Coiled-coil domain-containing protein 39, CCDC39 |
| Target/Specificity | This CCDC39 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 770-798 amino acids from the C-terminal region of human CCDC39. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCDC39 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CCDC39 (HGNC:25244) |
|---|---|
| Function | Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972). Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (PubMed:21131972). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme. Note=CCDC40 is required for localization to axonemes. |
| Tissue Location | Mainly expressed in nasal brushings and, to a lesser extent, in lungs and testis. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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¥ 1,250.00
Cat# AP11039b
