癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GNAT2 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P19087 |
| Other Accession | NP_005263.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40176 Da |
| Antigen Region | 140-169 aa |
| Gene ID | 2780 |
|---|---|
| Other Names | Guanine nucleotide-binding protein G(t) subunit alpha-2, Transducin alpha-2 chain, GNAT2, GNATC |
| Target/Specificity | This GNAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-169 amino acids from the Central region of human GNAT2. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GNAT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GNAT2 (HGNC:4394) |
|---|---|
| Synonyms | GNATC |
| Function | Alpha subunit of the heterotrimeric guanine nucleotide- binding protein (G protein) that transduces signals from the G protein- coupled cone photoreceptors (blue, green and red cones) (PubMed:12077706, PubMed:2534964). Functions as a GTPase, cycling between an active GTP-bound state and an inactive GDP-bound state. Upon photoactivation, cone photoreceptors promote GDP release and GTP binding (By similarity). In its active state, GNAT2 stimulates downstream effectors, including the cone cGMP-phosphodiesterase (PDE6) complex, to mediate the phototransduction cascade (By similarity). Activation of the PDE6 complex occurs through binding and repositioning of the inhibitory PDE6 gamma subunits (PDE6H), thereby promoting catalytic activity (By similarity). |
| Cellular Location | Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment |
| Tissue Location | Retinal cone photoreceptors. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones.
REFERENCES
Shi, J., et al. Mol. Psychiatry (2010) In press :
Thiadens, A.A., et al. Ophthalmology 116(10):1984-1989(2009)
Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)
Oldham, W.M., et al. Nat. Struct. Mol. Biol. 13(9):772-777(2006)
Rosenberg, T., et al. Invest. Ophthalmol. Vis. Sci. 45(12):4256-4262(2004)
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