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|Application ||WB, FC, E|
|Other Accession||Q52QT8, NP_004051|
|Calculated MW||34074 Da|
|Other Names||Cyclin-G1, Cyclin-G, CCNG1, CCNG, CYCG1|
|Target/Specificity||This CCNG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the C-terminal region of human CCNG1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCNG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).|
|Cellular Location||Nucleus. Note=DNA replication foci after DNA damage|
|Tissue Location||High levels in skeletal muscle, ovary, kidney and colon|
Provided below are standard protocols that you may find useful for product applications.
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq].
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009) Fornari, F., et al. Cancer Res. 69(14):5761-5767(2009) Li, H., et al. Mol. Cell. Biol. 29(3):919-928(2009) Piscopo, D.M., et al. Cancer Res. 68(14):5581-5590(2008) Seo, H.R., et al. J. Biol. Chem. 283(23):15601-15610(2008)