GAS2L2 Antibody (C-term) 精选

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Anti-GAS2L2 Antibody (C-term) at 1:1000 dilution + human skeletal muscle lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 97 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
GAS2L2 Antibody (C-term) (Cat. #AP11417b) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the GAS2L2 antibody detected the GAS2L2 protein (arrow).
GAS2L2 Antibody (C-term) (Cat. #AP11417b)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GAS2L2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, E
Primary Accession	Q8NHY3
Other Accession	NP_644814.1
Reactivity	Human
Predicted	Mouse, Rat, Bovine, Canine, Rabbit
Host	Rabbit
Clonality	Polyclonal
Isotype	Rabbit IgG
Calculated MW	96520 Da
Antigen Region	763-791 aa

Additional Information
Gene ID	246176
Other Names	GAS2-like protein 2, GAS2-related protein on chromosome 17, Growth arrest-specific protein 2-like 2, GAS2L2, GAR17
Target/Specificity	This GAS2L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 763-791 amino acids from the C-terminal region of human GAS2L2.
Dilution	WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration.
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions	GAS2L2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	GAS2L2
Synonyms	GAR17
Function	Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Enhances ADORA2- mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704).
Cellular Location	Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250\|UniProtKB:Q5SSG4}. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with ADORA2A at neuronal processes (By similarity). Colocalizes with and tracks the tips of microtubule plus ends (PubMed:24706950) {ECO:0000250\|UniProtKB:D3ZUE1, ECO:0000269\|PubMed:24706950}
Tissue Location	Expressed in bronchial and nasal epithelial cells (at protein level) (PubMed:30665704). Expressed in brain, kidney, lung, testis, fallopian tubes, and skeletal muscle (PubMed:12584248, PubMed:30665704). Expressed at low levels in stomach and colon (PubMed:30665704).