CPT1C Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, FC, E |
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Primary Accession | Q8TCG5 |
Other Accession | NP_001129524.1, NP_689572.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 90989 Da |
Antigen Region | 752-782 aa |
Gene ID | 126129 |
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Other Names | Carnitine O-palmitoyltransferase 1, brain isoform, CPT1-B, CPT IC, Carnitine O-palmitoyltransferase I, brain isoform, CPTI-B, Carnitine palmitoyltransferase 1C, CPT1C, CATL1 |
Target/Specificity | This CPT1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 752-782 amino acids from the C-terminal region of human CPT1C. |
Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CPT1C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CPT1C (HGNC:18540) |
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Synonyms | CATL1 |
Function | Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 (PubMed:30135643). Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (By similarity). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control (PubMed:16651524). Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels (PubMed:25751282, PubMed:30135643). |
Cellular Location | Cell projection, dendrite. Cell projection, axon. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized in the soma and dendritic and axonal projections. |
Tissue Location | Expressed predominantly in brain and testis. Expressed in motor neurons. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.

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