癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Neuropilin-2 Antibody (C-term K813)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 2
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O60462 |
| Other Accession | NP_003863.2, NP_957719.1, NP_061004.3, NP_957718.1, NP_958436.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 104831 Da |
| Antigen Region | 798-827 aa |
| Gene ID | 8828 |
|---|---|
| Other Names | Neuropilin-2, Vascular endothelial cell growth factor 165 receptor 2, NRP2, VEGF165R2 |
| Target/Specificity | This Neuropilin-2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 798-827 amino acids from the C-terminal region of human Neuropilin-2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Neuropilin-2 Antibody (C-term K813) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NRP2 |
|---|---|
| Synonyms | VEGF165R2 |
| Function | High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. |
| Cellular Location | Membrane; Single- pass type I membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
REFERENCES
Rey-Gallardo, A., et al. Glycobiology 20(9):1139-1146(2010)
Geretti, E., et al. Mol. Cancer Res. 8(8):1063-1073(2010)
Guo-ping, W., et al. Ann Plast Surg 65(1):80-84(2010)
Nasarre, C., et al. Cell Adh Migr 3(4):383-389(2009)
Fassold, A., et al. Arthritis Rheum. 60(10):2892-2901(2009)
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