癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PRSS21 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y6M0 |
| Other Accession | NP_659206.1, NP_006790.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34884 Da |
| Antigen Region | 165-193 aa |
| Gene ID | 10942 |
|---|---|
| Other Names | Testisin, 3421-, Eosinophil serine protease 1, ESP-1, Serine protease 21, PRSS21, ESP1, TEST1 |
| Target/Specificity | This PRSS21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human PRSS21. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRSS21 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRSS21 |
|---|---|
| Synonyms | ESP1, TEST1 |
| Function | Could regulate proteolytic events associated with testicular germ cell maturation. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor |
| Tissue Location | Expressed predominantly in premeiotic testicular germ cells, mostly late pachytene and diplotene spermatocytes |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. It is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and it may be involved in progression of testicular tumors of germ cell origin. Alternative splicing of this gene results in three transcript variants encoding three different isoforms. [provided by RefSeq].
REFERENCES
Yeom, S.Y., et al. FEBS Lett. 584(8):1469-1475(2010)
Netzel-Arnett, S., et al. Biol. Reprod. 81(5):921-932(2009)
Kempkensteffen, C., et al. J. Cancer Res. Clin. Oncol. 132(12):765-770(2006)
Manton, K.J., et al. Br. J. Cancer 92(4):760-769(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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