癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OTX2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P32243 |
| Other Accession | P80206, Q91981, Q6DKN2, Q91813, NP_068374.1, NP_758840.1 |
| Reactivity | Human, Mouse |
| Predicted | Mouse, Zebrafish, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31636 Da |
| Antigen Region | 261-289 aa |
| Gene ID | 5015 |
|---|---|
| Other Names | Homeobox protein OTX2, Orthodenticle homolog 2, OTX2 |
| Target/Specificity | This OTX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-289 amino acids from the C-terminal region of human OTX2. |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OTX2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OTX2 |
|---|---|
| Function | Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. |
| Cellular Location | Nucleus. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Masuda, T., et al. J. Biol. Chem. 285(35):26933-26944(2010)
Gonzalez-Rodriguez, J., et al. Br J Ophthalmol 94(8):1100-1104(2010)
Chung, C.Y., et al. Brain 133 (PT 7), 2022-2031 (2010) :
Ashkenazi-Hoffnung, L., et al. Hum. Genet. 127(6):721-729(2010)
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