癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KHSRP Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IF, WB, E |
|---|---|
| Primary Accession | Q92945 |
| Other Accession | Q99PF5, Q3U0V1, NP_003676.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 73115 Da |
| Antigen Region | 470-498 aa |
| Gene ID | 8570 |
|---|---|
| Other Names | Far upstream element-binding protein 2, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, KHSRP, FUBP2 |
| Target/Specificity | This KHSRP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-498 amino acids from the Central region of human KHSRP. |
| Dilution | IHC-P~~1:100~500 IF~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KHSRP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KHSRP |
|---|---|
| Synonyms | FUBP2 |
| Function | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue- specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. |
| Cellular Location | Nucleus. Cytoplasm. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. |
| Tissue Location | Detected in neural and non-neural cell lines. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).
REFERENCES
Michlewski, G., et al. Nat. Struct. Mol. Biol. 17(8):1011-1018(2010)
Bikkavilli, R.K., et al. J. Cell. Sci. 123 (PT 8), 1352-1362 (2010) :
Malz, M., et al. Hepatology 50(4):1130-1139(2009)
Trabucchi, M., et al. Nature 459(7249):1010-1014(2009)
Nechama, M., et al. BMC Cell Biol. 10, 70 (2009) :
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