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>   首页   >   产品   >   一抗   >   信号转导   >   NUP107 Antibody (Center)   

NUP107 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - NUP107 Antibody (Center) AP11787c
    NUP107 Antibody (Center) (Cat. #AP11787c) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the NUP107 antibody detected the NUP107 protein (arrow).
  • 14 - NUP107 Antibody (Center) AP11787c
    NUP107 Antibody (Center) (Cat. #AP11787c)immunohistochemistry analysis in formalin fixed and paraffin embedded human cervical tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NUP107 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P57740
Other Accession NP_065134.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 106374 Da
Antigen Region 398-425 aa
Additional Information
Gene ID 57122
Other Names Nuclear pore complex protein Nup107, 107 kDa nucleoporin, Nucleoporin Nup107, NUP107
Target/Specificity This NUP107 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 398-425 amino acids from the Central region of human NUP107.
Dilution WB~~1:1000
IHC-P~~1:100~500
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNUP107 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NUP107
Function Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:12552102, PubMed:15229283). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222).
Cellular Location Nucleus membrane. Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the NPC core structure (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). Dissociates from the dissasembled NPC structure late during prophase of mitosis (PubMed:11564755)
Tissue Location Ubiquitously expressed in fetal and adult tissues.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

REFERENCES

Kim, S.Y., et al. Biochem. Biophys. Res. Commun. 401(1):131-136(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Mishra, R.K., et al. Nat. Cell Biol. 12(2):164-169(2010)
Platani, M., et al. Mol. Biol. Cell 20(24):5260-5275(2009)
Whittle, J.R., et al. J. Biol. Chem. 284(41):28442-28452(2009)

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