癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GAS1 Antibody (N-term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IF, FC, E |
|---|---|
| Primary Accession | P54826 |
| Other Accession | Q01721, NP_002039 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35693 Da |
| Antigen Region | 95-127 aa |
| Gene ID | 2619 |
|---|---|
| Other Names | Growth arrest-specific protein 1, GAS-1, GAS1 |
| Target/Specificity | This GAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-127 amino acids from the N-terminal region of human GAS1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 IF~~1:10~50 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GAS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GAS1 {ECO:0000303|PubMed:8127893, ECO:0000312|HGNC:HGNC:4165} |
|---|---|
| Function | Coreceptor required for sonic hedgehog (SHH) handoff to its receptor: binds to the dually lipid-modified Sonic hedgehog protein N- product (ShhN) downstream of the CDON-BOC heterodimer and directly transfers ShhN to its patched receptor (PTCH1 or PTCH2), followed by activation of the smoothened signaling pathway (PubMed:35231446). Specifically recognizes and binds palmitate and cholesterol moieties in dually lipid-modified ShhN (PubMed:35231446). Binds 20(S)- hydroxycholesterol (20(S)-OHC) (By similarity). Acts as a growth arrest protein involved in growth suppression by blocking entry to S phase (PubMed:8127893). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q01721}; Extracellular side {ECO:0000250|UniProtKB:Q01721} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene.
REFERENCES
Ribeiro, L.A., et al. Am. J. Med. Genet. A 152A (7), 1688-1694 (2010) : Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) : Rittie, L., et al. Aging Cell 8(6):738-751(2009) Zhao, L., et al. J. Biol. Chem. 284(39):26273-26285(2009) Dominguez-Monzon, G., et al. Int. J. Dev. Neurosci. 27(4):305-313(2009)
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