癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PRDM5 (PFM2) Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| E |
|---|---|
| Primary Accession | Q9NQX1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 73090 Da |
| Gene ID | 11107 |
|---|---|
| Other Names | PR domain zinc finger protein 5, 211-, PR domain-containing protein 5, PRDM5, PFM2 |
| Target/Specificity | This PRDM5 (PFM2) antibody is generated from rabbits immunized with purified recombinant GST fusion protein encoding the N-terminal region of human PRDM5. |
| Dilution | E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRDM5 (PFM2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRDM5 |
|---|---|
| Synonyms | PFM2 |
| Function | Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells. |
| Cellular Location | Nucleus |
| Tissue Location | Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis.
REFERENCES
Xiao, B., et al., Curr. Opin. Struct. Biol. 13(6):699-705 (2003).
Jiang, G.L., et al., Histol. Histopathol. 15(1):109-117 (2000).
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