癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SOX3 Antibody (Center P204)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P41225 |
| Other Accession | P53784, Q6EJB7, P48433, Q5FWM3, P55863, Q2PG84, P53783, O00570, O57401, Q2Z1R2, Q6DGL6, NP_005625.2 |
| Reactivity | Human |
| Predicted | Zebrafish, Chicken, Mouse, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45210 Da |
| Antigen Region | 189-218 aa |
| Gene ID | 6658 |
|---|---|
| Other Names | Transcription factor SOX-3, SOX3 |
| Target/Specificity | This SOX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the Central region of human SOX3. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SOX3 Antibody (Center P204) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOX3 |
|---|---|
| Function | Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). |
| Cellular Location | Nucleus. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.
REFERENCES
Dateki, S., et al. J. Clin. Endocrinol. Metab. 95(8):4043-4047(2010)
Sato, Y., et al. Mol. Cell. Biochem. 337 (1-2), 267-275 (2010) :
Mojsin, M., et al. Biochem. J. 425(1):107-116(2010)
Bleyl, S.B., et al. Am. J. Med. Genet. A 143A (23), 2785-2795 (2007) :
Krstic, A., et al. Arch. Biochem. Biophys. 467(2):163-173(2007)
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