癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MOZ/MYST3 Antibody (C-term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q92794 |
| Other Accession | NP_001092882 |
| Reactivity | Human, Mouse |
| Predicted | Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 225028 Da |
| Antigen Region | 1319-1351 aa |
| Gene ID | 7994 |
|---|---|
| Other Names | Histone acetyltransferase KAT6A, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3, MYST-3, Monocytic leukemia zinc finger protein, Runt-related transcription factor-binding protein 2, Zinc finger protein 220, KAT6A, MOZ, MYST3, RUNXBP2, ZNF220 |
| Target/Specificity | This MOZ/MYST3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1319-1351 amino acids from the C-terminal region of human MOZ/MYST3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MOZ/MYST3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KAT6A (HGNC:13013) |
|---|---|
| Function | Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro) (PubMed:11742995, PubMed:11965546). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:11965546). May act as a transcriptional coactivator for RUNX1 and RUNX2 (PubMed:12771199). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (PubMed:23431171). May play a role in leukemogenic gene transcription (PubMed:39794553). |
| Cellular Location | Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, PML body. Note=Recruited into PML body after DNA damage |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Histone acetyltransferase which may act as a transcriptional coactivator for RUNX1 and RUNX2.
REFERENCES
Paggetti, J., et al. Oncogene 29(36):5019-5031(2010)
Rokudai, S., et al. J. Biol. Chem. 284(1):237-244(2009)
Murati, A., et al. Leukemia 23(1):85-94(2009)
Ullah, M., et al. Mol. Cell. Biol. 28(22):6828-6843(2008)
Katsumoto, T., et al. Cancer Sci. 99(8):1523-1527(2008)
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