癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MAFB Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9Y5Q3 |
| Other Accession | Q6DE84, P54842, P54841, Q2PFS4, NP_005452.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Monkey, Xenopus, Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35792 Da |
| Antigen Region | 266-292 aa |
| Gene ID | 9935 |
|---|---|
| Other Names | Transcription factor MafB, Maf-B, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, MAFB, KRML |
| Target/Specificity | This MAFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-292 amino acids from the C-terminal region of human MAFB. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAFB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MAFB |
|---|---|
| Synonyms | KRML |
| Function | Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid- specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. |
| Tissue Location | Ubiquitous.. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq].
REFERENCES
Kim, H., et al. Nat. Immunol. 11(8):743-750(2010)
Beaty, T.H., et al. Nat. Genet. 42(6):525-529(2010)
Vatsveen, T.K., et al. Leuk. Res. 33(12):1670-1677(2009)
Zanocco-Marani, T., et al. Exp. Cell Res. 315(11):1798-1808(2009)
Kathiresan, S., et al. Nat. Genet. 41(1):56-65(2009)
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