癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
F2RL2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O00254 |
| Other Accession | NP_004092.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42508 Da |
| Antigen Region | 21-50 aa |
| Gene ID | 2151 |
|---|---|
| Other Names | Proteinase-activated receptor 3, PAR-3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2, F2RL2, PAR3 |
| Target/Specificity | This F2RL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human F2RL2. |
| Dilution | WB~~1:500 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | F2RL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | F2RL2 |
|---|---|
| Synonyms | PAR3 |
| Function | Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Popovic, M., et al. J. Thromb. Thrombolysis 30(2):164-171(2010)
Van Laer, L., et al. Eur. J. Hum. Genet. 18(6):685-693(2010)
Wysoczynski, M., et al. Mol. Cancer Res. 8(5):677-690(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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