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GRIN3B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O60391 |
| Other Accession | NP_619635.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 112992 Da |
| Antigen Region | 904-933 aa |
| Gene ID | 116444 |
|---|---|
| Other Names | Glutamate receptor ionotropic, NMDA 3B, GluN3B, N-methyl-D-aspartate receptor subtype 3B, NMDAR3B, NR3B, GRIN3B |
| Target/Specificity | This GRIN3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 904-933 amino acids from the C-terminal region of human GRIN3B. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GRIN3B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRIN3B (HGNC:16768) |
|---|---|
| Function | Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+) (By similarity). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity). Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. GluN3B subunit also binds D-serine and, in the absence of glycine, activates glycinergic receptor complexes, but with lower efficacy than glycine (By similarity). Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q91ZU9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13224} Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q91ZU9} Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. {ECO:0000250|UniProtKB:Q91ZU9} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GRIN3B is a NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. It is mediated by glycine.
REFERENCES
Sedaghati, M., et al. Eur. J. Pharmacol. 633 (1-3), 50-54 (2010) :
Saus, E., et al. J Psychiatr Res (2010) In press :
Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)
Liu, H.P., et al. Dement Geriatr Cogn Disord 28(6):521-527(2009)
Niemann, S., et al. Neurology 70(9):666-676(2008)
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