癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TSN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| IHC-P, IF, WB, E |
|---|---|
| Primary Accession | Q15631 |
| Other Accession | Q62348, P97891, Q08DM8, NP_004613.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Hamster, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26183 Da |
| Antigen Region | 109-138 aa |
| Gene ID | 7247 |
|---|---|
| Other Names | Translin, 31--, Component 3 of promoter of RISC, C3PO, TSN |
| Target/Specificity | This TSN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human TSN. |
| Dilution | IHC-P~~1:100~500 IF~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TSN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSN (HGNC:12379) |
|---|---|
| Function | DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. |
| Cellular Location | Cytoplasm. Nucleus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.
REFERENCES
Chiaruttini, C., et al. Proc. Natl. Acad. Sci. U.S.A. 106(38):16481-16486(2009)
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :
Sengupta, K., et al. Biochemistry 45(3):861-870(2006)
Kaluzhny, D., et al. J. Biomol. Struct. Dyn. 23(3):257-265(2005)
Gupta, G.D., et al. FEBS Lett. 579(14):3141-3146(2005)
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