癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KCNJ13 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O60928 |
| Other Accession | NP_002233.2, NP_001165887.1 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40530 Da |
| Antigen Region | 67-95 aa |
| Gene ID | 3769 |
|---|---|
| Other Names | Inward rectifier potassium channel 13, Inward rectifier K(+) channel Kir71, Potassium channel, inwardly rectifying subfamily J member 13, KCNJ13 |
| Target/Specificity | This KCNJ13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-95 amino acids from the N-terminal region of human KCNJ13. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCNJ13 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNJ13 |
|---|---|
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. |
| Cellular Location | Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P86046} Note=Localized at the retinal pigmented epithelium (RPE) apical microvilli. {ECO:0000250|UniProtKB:P86046} |
| Tissue Location | Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associated with snowflake vitreoretinal degeneration. Alternate splicing results in multiple transcript variants.
REFERENCES
Zhang, W., et al. Biochem. Biophys. Res. Commun. 377(3):981-986(2008)
Ji, W., et al. Nat. Genet. 40(5):592-599(2008)
Hughes, B.A., et al. Am. J. Physiol., Cell Physiol. 294 (2), C423-C431 (2008) :
Hejtmancik, J.F., et al. Am. J. Hum. Genet. 82(1):174-180(2008)
Yang, D., et al. Exp. Eye Res. 86(1):81-91(2008)
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