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>   首页   >   产品   >   一抗   >   心血管   >   CNN2 Antibody (N-term)   

CNN2 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CNN2 Antibody (N-term) AP12417a
    CNN2 Antibody (N-term) (Cat. #AP12417a) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the CNN2 antibody detected the CNN2 protein (arrow).
  • 14 - CNN2 Antibody (N-term) AP12417a
    CNN2 Antibody (N-term) (Cat. #AP12417a)immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CNN2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q99439
Other Accession NP_004359.1, NP_958434.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33697 Da
Antigen Region 9-36 aa
Additional Information
Gene ID 1265
Other Names Calponin-2, Calponin H2, smooth muscle, Neutral calponin, CNN2
Target/Specificity This CNN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-36 amino acids from the N-terminal region of human CNN2.
Dilution WB~~1:1000
IHC-P~~1:100~500
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCNN2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNN2
Function Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Tissue Location Heart and smooth muscle.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene.

REFERENCES

Rikova, K., et al. Cell 131(6):1190-1203(2007)
Hossain, M.M., et al. J. Biol. Chem. 280(51):42442-42453(2005)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Hossain, M.M., et al. Am. J. Physiol., Cell Physiol. 284 (1), C156-C167 (2003) :

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