癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MLXIPL Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9NP71 |
| Other Accession | NP_116571.1, NP_116569.1 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 93073 Da |
| Antigen Region | 624-653 aa |
| Gene ID | 51085 |
|---|---|
| Other Names | Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, bHLHd14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, WS-bHLH, Williams-Beuren syndrome chromosomal region 14 protein, MLXIPL, BHLHD14, MIO, WBSCR14 |
| Target/Specificity | This MLXIPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-653 amino acids from the C-terminal region of human MLXIPL. |
| Dilution | IHC-P~~1:100~500 WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MLXIPL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MLXIPL |
|---|---|
| Synonyms | BHLHD14, MIO, WBSCR14 |
| Function | Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in liver, heart, kidney, cerebellum and intestinal tissues |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.
REFERENCES
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010)
Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010)
Chidambaram, M., et al. Metab. Clin. Exp. (2010) In press :
Reynolds, C.A., et al. Hum. Mol. Genet. 19(10):2068-2078(2010)
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