癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DRG1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, FC, WB, E |
|---|---|
| Primary Accession | Q9Y295 |
| Other Accession | P32233, Q3MHP5, NP_004138.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40542 Da |
| Antigen Region | 334-363 aa |
| Gene ID | 4733 |
|---|---|
| Other Names | Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, NEDD-3, DRG1, NEDD3 |
| Target/Specificity | This DRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-363 amino acids from the C-terminal region of human DRG1. |
| Dilution | IHC-P~~1:100~500 FC~~1:10~50 WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DRG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DRG1 {ECO:0000303|PubMed:29915238, ECO:0000312|HGNC:HGNC:3029} |
|---|---|
| Function | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:23711155, PubMed:29915238, PubMed:37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). |
| Cellular Location | Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes |
| Tissue Location | High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DRG1 may play a role in cell proliferation, differentiation and death.
REFERENCES
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Bandyopadhyay, S., et al. Cancer Res. 66(24):11983-11990(2006)
Bandyopadhyay, S., et al. Oncogene 23(33):5675-5681(2004)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Bandyopadhyay, S., et al. Cancer Res. 63(8):1731-1736(2003)
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Cat# AP12620b
