癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DOC2A Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| FC, WB, IHC-P, E |
|---|---|
| Primary Accession | Q14183 |
| Other Accession | Q14184, P70611, Q7TNF0, NP_003577.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43959 Da |
| Antigen Region | 277-306 aa |
| Gene ID | 8448 |
|---|---|
| Other Names | Double C2-like domain-containing protein alpha, Doc2, Doc2-alpha, DOC2A |
| Target/Specificity | This DOC2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-306 amino acids from the Central region of human DOC2A. |
| Dilution | FC~~1:10~50 WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DOC2A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DOC2A |
|---|---|
| Function | Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. |
| Cellular Location | Lysosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Synapse, synaptosome |
| Tissue Location | Predominantly expressed in brain. Also expressed in testis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.
REFERENCES
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Glessner, J.T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(23):10584-10589(2010)
Guilmatre, A., et al. Arch. Gen. Psychiatry 66(9):947-956(2009)
Kumar, R.A., et al. PLoS ONE 4 (2), E4582 (2009) :
Higashio, H., et al. J. Immunol. 180(7):4774-4784(2008)
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