癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC15A3 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8IY34 |
| Other Accession | Q924V4, Q8BPX9, NP_057666.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Rat, Bovine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 63560 Da |
| Antigen Region | 168-197 aa |
| Gene ID | 51296 |
|---|---|
| Other Names | Solute carrier family 15 member 3, Osteoclast transporter, Peptide transporter 3, Peptide/histidine transporter 2, SLC15A3, OCTP, PHT2, PTR3 |
| Target/Specificity | This SLC15A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the Central region of human SLC15A3. |
| Dilution | IHC-P~~1:50~200 WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC15A3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC15A3 (HGNC:18068) |
|---|---|
| Function | Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (PubMed:39719710). Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position (PubMed:39719710). Also able to transport carnosine (PubMed:31073693, PubMed:31254495). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). |
| Cellular Location | Lysosome membrane; Multi-pass membrane protein. Endosome membrane {ECO:0000250|UniProtKB:Q8BPX9}; Multi-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SLC15A3 is proton oligopeptide cotransporter. Transports free histidine and certain di-and tripeptides (By similarity).
REFERENCES
Daniel, H., et al. Pflugers Arch. 447(5):610-618(2004) Sakata, K., et al. Biochem. J. 356 (PT 1), 53-60 (2001) : Botka, C.W., et al. AAPS PharmSci 2 (2), E16 (2000) :
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