PON2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IHC-P, FC, E |
---|---|
Primary Accession | Q15165 |
Other Accession | NP_000296.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 39381 Da |
Antigen Region | 79-107 aa |
Gene ID | 5445 |
---|---|
Other Names | Serum paraoxonase/arylesterase 2, PON 2, Aromatic esterase 2, A-esterase 2, Serum aryldialkylphosphatase 2, PON2 |
Target/Specificity | This PON2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the N-terminal region of human PON2. |
Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PON2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PON2 |
---|---|
Function | Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. |
Cellular Location | Membrane; Peripheral membrane protein |
Tissue Location | Widely expressed with highest expression in liver, lung, placenta, testis and heart. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Altenhofer, S., et al. J. Biol. Chem. 285(32):24398-24403(2010)
Ticozzi, N., et al. Ann. Neurol. 68(1):102-107(2010)
Wang, Y., et al. Diabet. Med. 27(4):376-383(2010)
Cross, D.S., et al. BMC Genet. 11, 51 (2010) :

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问,联系:0512-88856768 tech-china@abcepta.com.