MORN3 Antibody (Center) 精选

Affinity Purified Rabbit Polyclonal Antibody (Pab)

MORN3 Antibody (Center) (Cat. #AP12954c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the MORN3 antibody detected the MORN3 protein (arrow).
MORN3 Antibdy (Center) (Cat. #AP12954c)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MORN3 Antibdy (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, E
Primary Accession	Q6PF18
Other Accession	NP_776254.3
Reactivity	Human
Predicted	Mouse, Rat, Bovine, Canine, Rabbit
Host	Rabbit
Clonality	Polyclonal
Isotype	Rabbit IgG
Calculated MW	27585 Da
Antigen Region	128-157 aa

Additional Information
Gene ID	283385
Other Names	MORN repeat-containing protein 3, MORN3
Target/Specificity	This MORN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human MORN3.
Dilution	WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration.
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions	MORN3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	MORN3 (HGNC:29807)
Function	Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors (PubMed:29681526). May play a role in the regulation of spermatogenesis (By similarity).
Cellular Location	Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250\|UniProtKB:Q8C5T4}. Note=Localized in the acrosome in germ cells throughout spermiogenesis, it is also present in the manchette of elongating spermatids. {ECO:0000250\|UniProtKB:Q8C5T4}

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.