癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SIM1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | P81133 |
| Other Accession | P05709, Q61045, NP_005059.2 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Mouse, Drosophila |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 85515 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 6492 |
|---|---|
| Other Names | Single-minded homolog 1, Class E basic helix-loop-helix protein 14, bHLHe14, SIM1, BHLHE14 |
| Target/Specificity | This SIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SIM1. |
| Dilution | IHC-P-Leica~~1:250 WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SIM1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SIM1 |
|---|---|
| Synonyms | BHLHE14 |
| Function | Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00632, ECO:0000255|PROSITE-ProRule:PRU00981} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome.
REFERENCES
Ghoussaini, M., et al. Obesity (Silver Spring) 18(8):1670-1675(2010)
Tolson, K.P., et al. J. Neurosci. 30(10):3803-3812(2010)
Traurig, M., et al. Diabetes 58(7):1682-1689(2009)
Gregorio, S.P., et al. Psychiatry Res 165 (1-2), 1-9 (2009) :
Hung, C.C., et al. Int J Obes (Lond) 31(3):429-434(2007)
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