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>   首页   >   产品   >   一抗   >   癌症   >   FSHB/FSH Antibody (Center)   

FSHB/FSH Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FSHB/FSH Antibody (Center) AP13055c
    FSHB/FSH Antibody (Center) (Cat. #AP13055c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the FSHB/FSH antibody detected the FSHB/FSH protein (arrow).
  • 4 - FSHB/FSH Antibody (Center) AP13055c
    FSHB/FSH Antibody (Center) (Cat. #AP13055c) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, E
Primary Accession P01225
Other Accession NP_001018090.1, NP_000501.1
Reactivity Human, Rat, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 14700 Da
Antigen Region 36-64 aa
Additional Information
Gene ID 2488
Other Names Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain, FSHB
Target/Specificity This FSHB/FSH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the Central region of human FSHB/FSH.
Dilution WB~~1:1000
FC~~1:10~50
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFSHB/FSH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FSHB
Function Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:24692546, PubMed:2494176). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).
Cellular Location Secreted. Note=Efficient secretion requires dimerization with CGA
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.

REFERENCES

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Corpuz, P.S., et al. Mol. Endocrinol. 24(5):1037-1051(2010)
Grigorova, M., et al. J. Clin. Endocrinol. Metab. 95(1):100-108(2010)
Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009)
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)

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